Gastric retention technique
The hydrophilic gel skeleton material and swelling agent are mixed with the drug to press the tablet. After the tablet contacts the medium, its weight is less than the generated buoyancy, so it can float rapidly on the upper part of gastric juice, and the floating time can last for more than 24 hours; After absorbing water from gastric juice, tablets will expand to several times their original volume, achieving the purpose of size exclusion. The combination of gastric flotation technology and size exclusion prolongs the gastric retention time of the combination, allowing better absorption of the drug at the absorption site and thus improving the bioavailability of the drug; The individual differences under different physiological conditions are reduced through the strong gel strength of the skeleton material and its dissolution characteristics.
DiQi Pharma has developed different products such as metformin hydrochloride sustained-release tablets, pregabalin sustained-release tablets, and lenalidomide sustained-release tablets using gastric retention technology.
Enteric coating technology
Enteric coating technology is usually a technique of coating tablets or pill cores to control the release of drugs in the intestine, used to protect acid resistant drugs from damage in acidic environments or to protect the gastric mucosa from the effects of irritating drugs. Usually, fluidized bed or extrusion rolling coating machines are used for spray coating of pill cores, or high-efficiency coating machines are used for spray coating of tablets, resulting in formulations with good acid resistance. The enteric coating technology is relatively mature, especially suitable for enteric coated preparations of acid resistant drugs such as azoles. Diqi Pharma has developed different products such as Lansoprazole enteric coated orally disintegrating tablets, Rabeprazole sodium enteric coated tablets, and Roxithromycin dispersible tablets using enteric coating technology.
Skeleton drug release technology
Skeleton drug release technology evenly disperses drugs in polymer skeleton materials, resulting in sustained drug release in aqueous environments due to the dissolution and dissolution of drugs or excipients. Skeleton tablets can be divided into insoluble skeleton sustained and controlled release tablets, hydrophilic gel skeleton sustained and controlled release tablets, waxy skeleton sustained and controlled release tablets and mixed material skeleton sustained and controlled release tablets according to the different skeleton materials of the preparation. Among them, hydrophilic gel matrix sustained-release tablets have the advantages of simple technology, easy amplification and low cost, accounting for 60%~70% of the listed matrix tablets.
Diqi Pharma has developed different products using skeleton release technology, including sustained-release tablets of morphine sulfate, sustained-release tablets of trimetazidine hydrochloride, sustained-release tablets of cefaclor, sustained-release tablets of indapamide, and sustained-release tablets of metformin hydrochloride.
