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PLGA
Basic Information
Basic Information
  • 【Chinese name】丙交酯乙交酯共聚物
  • 【English name】Poly-(d,l-lactide-co-glycolide).
  • 【Other names】PLGA
  • 【CAS number】26780-50-7
  • 【Product Grade】Pharmaceutical grade, for injection
  • 【Appearance】Stick-like particles.
  • 【Model】50/50, 65/35, 75/25, 85/15, 95/05, 100/0, can be customized.
  • 【Packaging Specification】0-1000g, can be customized.
  • 【Storage conditions】Sealed and stored at -20°C.
Application Scope
PLGA is an important class of biomedical polymer materials that combines the advantages of two polyester materials, polylactic acid (PLA) and polyglycolic acid (PGA), with good biocompatibility and degradability. It is widely used in the biomedical field, such as surgical sutures, fracture internal fixation materials, tissue repair materials, and drug controlled release systems. The main advantage of bioabsorbable polymers is that they are hydrolyzed and degraded into monomers, breaking down the components lactic acid and glycolic acid - both of which are absorbed by the body. The degradation degree of PLGA varies with different monomer ratios, and the higher the proportion of ethyl ester, the easier it is to degrade. PLGA has been approved for human use by drug review centers worldwide, including the United States, European Union, China, Japan, and other countries and regions, and is safe and reliable.
Application Cases
Application cases of injection preparations
Product name Manufacturer Indications Dosage form Polymer model
Risperidone microspheres for injection Janssen Schizophrenia Microspheres 75/25
Leuprorelin Acetate Microspheres For Injection Takeda Breast cancer Microspheres 75/25 95/05 100/0
Goserelin Acetate Sustained-Release Depot AstraZeneca Prostate cancer Subcutaneous implants 50/50 95/05
Dexamethasone intravitreal implant Allergan Macular edema Vitreous implant 50/50
Medical Device Application Cases
Coronary drug-eluting stent: The stent material is 316 stainless steel, the polymer is PLGA, and the drug is rapamycin.
VICRYL surgical suture: PLGA9010, absorbed within 3 months.
Advantages of DiQi PLGA excipients
  • 1. Complete models, stable quality, and 36 months of long-term stability research data have been obtained.
  • 2. Multiple self-developed long-acting microsphere formulations are already in use, and one drug has obtained clinical approval.
  • 3. Support customized and process research based on the specific molecular weight, viscosity, and other requirements of different drugs.
  • 4. Provide related declarations that comply with Chinese and American registration regulations and ensure stable supply after product launch.




Product Model
Model Register
China CDE Registration DMF registration in the United States
100/0
95/05
85/15
75/25
65/35
50/50

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